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Y Mitsui, R Takashima, M Fujimoto, T Kashiyama; Deposits of mucosubstances on the cornea by topical chloramphenicol: an electron microscopic study.. Invest. Ophthalmol. Vis. Sci. 1976;15(3):211-213. doi: https://doi.org/.
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Chloramphenicol was instilled into rabbit eyes and five days later the corneal surface was examined by scanning electron microscopy. The corneal surface was roughened and showed a proliferative appearance. Examination of thin sections of the cornea by transmission electron microscope showed that the corneal surface stained strongly with alcian blue. It was thus supposed to be a deposit of mucosubstances. Mucosubstances increase pathogenicity of bacteria and, therefore, this deposit may accelerate Pseudomonas keratitis after chloramphenicol application.
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