March 1976
Volume 15, Issue 3
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Articles  |   March 1976
Deposits of mucosubstances on the cornea by topical chloramphenicol: an electron microscopic study.
Investigative Ophthalmology & Visual Science March 1976, Vol.15, 211-213. doi:
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      Y Mitsui, R Takashima, M Fujimoto, T Kashiyama; Deposits of mucosubstances on the cornea by topical chloramphenicol: an electron microscopic study.. Invest. Ophthalmol. Vis. Sci. 1976;15(3):211-213.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Chloramphenicol was instilled into rabbit eyes and five days later the corneal surface was examined by scanning electron microscopy. The corneal surface was roughened and showed a proliferative appearance. Examination of thin sections of the cornea by transmission electron microscope showed that the corneal surface stained strongly with alcian blue. It was thus supposed to be a deposit of mucosubstances. Mucosubstances increase pathogenicity of bacteria and, therefore, this deposit may accelerate Pseudomonas keratitis after chloramphenicol application.

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