March 1976
Volume 15, Issue 3
Articles  |   March 1976
Chlorampenicol retention on, and penetration into, the rabbit eye.
Investigative Ophthalmology & Visual Science March 1976, Vol.15, 220-222. doi:
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      K Green, D L MacKeen; Chlorampenicol retention on, and penetration into, the rabbit eye.. Invest. Ophthalmol. Vis. Sci. 1976;15(3):220-222. doi:

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The retention of the antibiotic chloramphenicol on, and penetration into, the rabbit eye has been compared following administration in two vehicles. Samples were taken of both aqueous humor and a washing fluid applied to the conjunctival surface and the concentration of 14C-chloramphenicol determined. Greater tear film and aqueous humor drug concentrations, which are effective against many organisms, were found with a vehicle which enhanced retention time on the ocular surfaces.


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