March 1976
Volume 15, Issue 3
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Articles  |   March 1976
Chlorampenicol retention on, and penetration into, the rabbit eye.
Investigative Ophthalmology & Visual Science March 1976, Vol.15, 220-222. doi:https://doi.org/
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      K Green, D L MacKeen; Chlorampenicol retention on, and penetration into, the rabbit eye.. Invest. Ophthalmol. Vis. Sci. 1976;15(3):220-222. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The retention of the antibiotic chloramphenicol on, and penetration into, the rabbit eye has been compared following administration in two vehicles. Samples were taken of both aqueous humor and a washing fluid applied to the conjunctival surface and the concentration of 14C-chloramphenicol determined. Greater tear film and aqueous humor drug concentrations, which are effective against many organisms, were found with a vehicle which enhanced retention time on the ocular surfaces.

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