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B H Iglewski, R P Burns, I K Gipson; Pathogenesis of corneal damage from pseudomonas exotoxin A.. Invest. Ophthalmol. Vis. Sci. 1977;16(1):73-76.
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Pseudomonas aeruginosa exotoxin A was injected into rabbit corneas. Death of epithelial, endothelial, and stromal cells resulted, and necrosis of the cornea followed. Control eyes with exotoxin neutralized by specific antitoxin showed minimal damage. A dose-response pattern was evident. Antitoxin neutralization of pseudomonas exotoxin A in corneal ulcers may have possible therapeutic implications.
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