January 1977
Volume 16, Issue 1
Articles  |   January 1977
Pathogenesis of corneal damage from pseudomonas exotoxin A.
Investigative Ophthalmology & Visual Science January 1977, Vol.16, 73-76. doi:
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      B H Iglewski, R P Burns, I K Gipson; Pathogenesis of corneal damage from pseudomonas exotoxin A.. Invest. Ophthalmol. Vis. Sci. 1977;16(1):73-76.

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      © ARVO (1962-2015); The Authors (2016-present)

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Pseudomonas aeruginosa exotoxin A was injected into rabbit corneas. Death of epithelial, endothelial, and stromal cells resulted, and necrosis of the cornea followed. Control eyes with exotoxin neutralized by specific antitoxin showed minimal damage. A dose-response pattern was evident. Antitoxin neutralization of pseudomonas exotoxin A in corneal ulcers may have possible therapeutic implications.


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