July 1977
Volume 16, Issue 7
Articles  |   July 1977
Cataractogenic effects of a boron hydride disulfide compound.
Investigative Ophthalmology & Visual Science July 1977, Vol.16, 654-657. doi:
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      H N Fukui, S Iwata, D L Epstein, L O Merola; Cataractogenic effects of a boron hydride disulfide compound.. Invest. Ophthalmol. Vis. Sci. 1977;16(7):654-657.

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      © ARVO (1962-2015); The Authors (2016-present)

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The disulfide form but not the sulfhydryl form of a boron hydride compound was found to be cataractogenic. Apparently this compound attaches to the sulfhydryl group of Na-K ATPase in the lens epithelium inactivating this crucial enzyme. The consequence is that a defect in the cation pump activity arises, leading to a rapid influx of Na ions and loss of K ions and marked increase in hydration. These changes are thought to lead to opacification.


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