September 1976
Volume 15, Issue 9
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Articles  |   September 1976
An improved model of experimentally induced ocular hypertension in the rabbit.
Investigative Ophthalmology & Visual Science September 1976, Vol.15, 781-784. doi:
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      L Bonomi, L Tomazzoli, D Jaria; An improved model of experimentally induced ocular hypertension in the rabbit.. Invest. Ophthalmol. Vis. Sci. 1976;15(9):781-784.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A model of experimentally induced ocular hypertension for the evaluation of antiglaucoma drugs in the unanesthetized rabbit is described. It is based on the intravenous infusion of suitable amounts of 5 per cent glucose solution, and advantageously substitutes the oral water load. The method is sensitive to drugs acting both on the outflow facility (2 per cent pilocarpine) and an aqueous humor formation (10 per cent guanethidine).

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