July 1977
Volume 16, Issue 7
Articles  |   July 1977
Embryopathic effect of ophthalmic EDTA.
Investigative Ophthalmology & Visual Science July 1977, Vol.16, 652-654. doi:
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      A R Gasset, T Akaboshi; Embryopathic effect of ophthalmic EDTA.. Invest. Ophthalmol. Vis. Sci. 1977;16(7):652-654.

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      © ARVO (1962-2015); The Authors (2016-present)

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Studies on the potential teratogenic effect of topically applied EDTA (0.1% and 3%) were undertaken because of its proven teratogenic effects when administered systemically and because of its wide use as an ophthalmic drug. Although no teratogenic effect was found for either 0.1% or 3% solution of EDTA, 3% EDTA applied topically to the eye six times a day has a significant embryopathic effect, with only 30% of the progeny remaining normal.


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