February 1980
Volume 19, Issue 2
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Articles  |   February 1980
Effects of various pharmacologic agents on allergic inflammation of the eye. The roles of chemical mediators in ocular inflammation.
Investigative Ophthalmology & Visual Science February 1980, Vol.19, 176-181. doi:
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      M Okada, K Shimada; Effects of various pharmacologic agents on allergic inflammation of the eye. The roles of chemical mediators in ocular inflammation.. Invest. Ophthalmol. Vis. Sci. 1980;19(2):176-181.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Effects of pharmacologic agents on experimental ocular inflammation induced by reverse passive Arthus reactions were investigated by a slit-lamp technique utilizing fluorescein-labeled rabbet serum albumin as an indicator. Cobra venom factor completely eliminated inflammatory responses, indicating that the complement system is a trigger for this type of ocular inflammation. Antihistamines mainly suppressed the early vascular response. Reserpine and indomethacin remarkably inhibited the increase of the permeability of the blood-aqueous barrier over the first 5 hr. Epinephrine and steroid hormone were also effective. Neither diethylcarbamazine nor isonicotinic acid showed effects on the permeability changes induced in this type of inflammation.

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