December 1980
Volume 19, Issue 12
Articles  |   December 1980
Influence of chlorpromazine on the rabbit electroretinogram.
Investigative Ophthalmology & Visual Science December 1980, Vol.19, 1449-1456. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J M Jagadeesh, H C Lee, M Salazar-Bookaman; Influence of chlorpromazine on the rabbit electroretinogram.. Invest. Ophthalmol. Vis. Sci. 1980;19(12):1449-1456.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

In anesthetized albino or nonalbino rabbits, a 3 to 8 mg/kg IV injection of chlorpromazine did not affect a-wave amplitude of the electroretinogram (ERG). However, immediately after the injection of the drug, b-wave amplitude increased. The maximum increase occurred between 35 to 50 min, and the recovery time varied between 5 to 8 hr. Initial changes in the b-wave amplitude to some extent were affected by systemic changes in the blood pressure. However, the b-wave amplitude remained high for a long time after the blood pressure reached preinjection value, indicating a local effect of the drug. There was no change in a- or b-wave latencies. Although in vitro a large quantity of chlorpromazine can be localized in the melanin granules from pigmented rabbit retina, in vivo the ERG b-wave changes caused by the small intravenous dose of the drug were similar in both albino and nonalbino rabbits.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.