March 1980
Volume 19, Issue 3
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Articles  |   March 1980
Immediate effect of epinephrine on aqueous formation in the normal human eye as measured by fluorophotometry.
Investigative Ophthalmology & Visual Science March 1980, Vol.19, 256-266. doi:
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      D J Townsend, R F Brubaker; Immediate effect of epinephrine on aqueous formation in the normal human eye as measured by fluorophotometry.. Invest. Ophthalmol. Vis. Sci. 1980;19(3):256-266.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Epinephrine hydrochloride (1%) and an identical-appearing placebo were instilled into the right/left eye pairs (random assignment) of 24 young normal subjects. Aqueous humor flow (measured by fluorophotometry over a 7 hr period), intraocular pressure, and (in 10 subjects) tonographic facility of outflow were measured. The effects of epinephrine were to lower intraocular pressure (2.8 mm Hg +/- 1.9, mean +/- S.D.), raise the facility of outflow (37.4% +/- 21.7), and increase the rate of formation of aqueous humor (18.6% +/- 18.1). By comparing tonographic and fluorophotometric data in the same subjects, it was postulated that epinephrine increases the rate of outflow via the pressure-insensitive (uveoscleral, uveovortex) outflow pathway.

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