February 1980
Volume 19, Issue 2
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Articles  |   February 1980
The acceptance of a vitreous carbon alloplastic material, Proplast, in the rabbit eye.
Investigative Ophthalmology & Visual Science February 1980, Vol.19, 182-191. doi:
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      J C Barber, F Feaster, D Priour; The acceptance of a vitreous carbon alloplastic material, Proplast, in the rabbit eye.. Invest. Ophthalmol. Vis. Sci. 1980;19(2):182-191.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Proplast, a vitreous, carbon-Teflon, fluorocarbon polymer, was tested in rabbits for corneal tolerance and acceptance. Toxicity, vascularization, epithelialization, infection, and extrusion were studied clinically and histologically. Four techniques were used: implantation of irregular-shaped pieces of material in an interlamellar corneal pocket, lamellar graft implantation with one exposed surface, full-thickness corneal implants in a manner similar to penetrating keratoplasty, and full-thickness implants covered by a conjunctival flap. Results showed that Proplast allows fibrovascular ingrowth and stabilization without a significant foreign body response or encapsulation for a period of observation from 6 weeks to 4 months. Evidence of epithelial coverage and epithelial ingrowth was also found. Coverage of the Proplast with conjunctiva or corneal tissue was essential to prevent extrusion and infection.

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