February 1981
Volume 20, Issue 2
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Articles  |   February 1981
Assessment of acyclovir on acute ocular infection induced by drug-resistant strains of HSV-1.
Investigative Ophthalmology & Visual Science February 1981, Vol.20, 230-235. doi:
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      M D Trousdale, A B Nesburn, C A Miller; Assessment of acyclovir on acute ocular infection induced by drug-resistant strains of HSV-1.. Invest. Ophthalmol. Vis. Sci. 1981;20(2):230-235.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Effects of topical acyclovir treatment on rabbit eyes infected with parent McKrae, idoxuridine-resistant, and vidarabine-resistant strains of HSV-1 were studied. Topical acyclovir therapy given four times a day was significantly more effective than idoxuridine and vidarabine at suppressing acute herpetic ocular disease induced by either sensitive or drug-resistant strains of HSV-1. Virus isolation from neural tissues indicated that none of the therapy prevented viral infection of the nervous system.

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