March 1980
Volume 19, Issue 3
Articles  |   March 1980
Circadian rhythms and variability of the clinical electro-oculogram.
Investigative Ophthalmology & Visual Science March 1980, Vol.19, 278-288. doi:
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      M L Anderson, R L Purple; Circadian rhythms and variability of the clinical electro-oculogram.. Invest. Ophthalmol. Vis. Sci. 1980;19(3):278-288.

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      © ARVO (1962-2015); The Authors (2016-present)

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Clinical electro-oculograms (EOGs) were recorded from six normal subjects over 24 hr time periods for a total number of 70 EOG'S. Results indicate an inverse relationship exists between the light/dark (L/D) ratio and the dark-trough potential. No relationship was found between the light-peak potential and the L/D ratio. Both the dark-trough potential and the L/D ratio showed a circadian periodicity over working daylight hours and rather aberrant behavior in late evening and early morning hours. Circadian contributions to the L/D ratio are estimated to be between 20% and 50% of the total variability in the normal individuals studied. We suggest the optimal time for single measurements of EOG pathology should be around midday.


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