June 1982
Volume 22, Issue 6
Articles  |   June 1982
The occurrence of glutathione-insulin transhydrogenase in the retina.
Investigative Ophthalmology & Visual Science June 1982, Vol.22, 715-719. doi:https://doi.org/
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P T Varandani, D T Organisciak, M A Nafz; The occurrence of glutathione-insulin transhydrogenase in the retina.. Invest. Ophthalmol. Vis. Sci. 1982;22(6):715-719. doi: https://doi.org/.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

Insulin-degrading activity in the retina of cattle, rat, and rabbit has been studied. On the basis of activation by reduced glutathione, complete inhibition by N-ethylmaleimide, identification of one of the reaction products as the A chain of insulin, and reaction with antibody to purified beef pancreatic glutathione-insulin transhydrogenase, it is concluded that the insulin-degrading enzyme occurs in the retina. Preliminary studies showed that there is no difference in the levels of enzyme activity in retinal homogenates from cattle, rats, or rabbits and that the rat rod outer segments are probably devoid of the degrading activity.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.