April 1980
Volume 19, Issue 4
Articles  |   April 1980
Mucus-stimulating factor in tears.
Investigative Ophthalmology & Visual Science April 1980, Vol.19, 430-432. doi:
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      R M Franklin, B G Bang; Mucus-stimulating factor in tears.. Invest. Ophthalmol. Vis. Sci. 1980;19(4):430-432.

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      © ARVO (1962-2015); The Authors (2016-present)

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Mechanisms responsible for regulation of tear film mucus are poorly understood. Humoral factors responsible for stimulation of mucus secretion can be studied in vitro by using the free-swimming urn cell, a normal component of the coelomic fluid of the marine invertebrate Sipunculus nudus. With this system, a tear mucus-stimulating factor was found in normal human tears but was markedly decreased in patients with dry eye syndromes. It is suggested that a mucus-stimulating factor exists in normal human tears and that a decrease in this substance may be instrumental in the pathophysiology of certain dry eye syndromes.


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