February 1981
Volume 20, Issue 2
Articles  |   February 1981
Regeneration of retinal limiting membranes after chorioretinal biopsy in dogs.
Investigative Ophthalmology & Visual Science February 1981, Vol.20, 246-251. doi:https://doi.org/
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      I J Constable, R Horne, D H Slatter, G H Chester, R L Cooper; Regeneration of retinal limiting membranes after chorioretinal biopsy in dogs.. Invest. Ophthalmol. Vis. Sci. 1981;20(2):246-251. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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After chorioretinal biopsy in dogs, obtained without vitreous loss, accessory glial cells and fibroblasts filled the defect between cortical vitreous and bare sclera. The proliferating glial cells laid down a new basement membrane which was complete both on the internal and external aspects of the defect. After biopsy complicated by vitreous loss, however, cellular proliferation failed to re-establish complete internal and external limiting membranes, and new formed fibroblastic tissue extended into the vitreous. To our knowledge, this is the first report to describe effective regeneration of the internal limiting membrane of the retina in any species. These findings suggest that when vitreous loss can be avoided, healed chorioretinal biopsies are unlikely to lead to delayed pathological complications.


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