June 1982
Volume 22, Issue 6
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Articles  |   June 1982
N-ethylmaleimide increases the facility of aqueous outflow of excised monkey and calf eyes.
Investigative Ophthalmology & Visual Science June 1982, Vol.22, 752-756. doi:
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      D L Epstein, M M Patterson, S C Rivers, P J Anderson; N-ethylmaleimide increases the facility of aqueous outflow of excised monkey and calf eyes.. Invest. Ophthalmol. Vis. Sci. 1982;22(6):752-756.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Freshly enucleated eyes were quantitatively perfused via the anterior chamber at 15 mm Hg pressure with various concentrations of the sulfhydryl (-SH) agent. N-ethylmaleimide (NEM). In the monkey eye a dosage of 9.4 mM NEM produced a 108% increase in facility of outflow. In calf eyes a dosage of NEM of 4.7 mM or greater also produced a significant increase in outflow facility. At the threshold dosage of 4.7 mM NEM there was only slight (12%) inhibition of glycolysis in the calf meshwork, which was excised after perfusion. The results suggest that the effect of NEM on outflow facility is not caused by a metabolic inhibitory action. We propose that alteration of cell membrane -SH groups in the outflow pathways can influence aqueous outflow resistance.

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