November 1981
Volume 21, Issue 5
Articles  |   November 1981
Suppression of adrenergic adaptation in the eye with a prostaglandin synthesis inhibitor.
Investigative Ophthalmology & Visual Science November 1981, Vol.21, 756-759. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R M Duffin, R E Christensen, M V Bergamini; Suppression of adrenergic adaptation in the eye with a prostaglandin synthesis inhibitor.. Invest. Ophthalmol. Vis. Sci. 1981;21(5):756-759. doi:

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

The treatment of glaucoma patients with a topical medication is sometimes associated with adaptation (the development of subsensitivity) to the effect of the medication. In the rabbit eye, adaptation develops when norepinephrine is administered topically on a daily basis. A marked decrease in the intraocular pressure is observed the first day, but diminishing responses are observed on subsequent days. Since prostaglandins may be released in response to catecholamines and have been found to inhibit adrenergic neurotransmission, we treated rabbits with topical flurbiprofen, a potent cyclooxygenase (prostaglandin synthesis) inhibitor, to suppress adaptation to norepinephrine. The results demonstrate a significant suppression of adaptation in the concentration range of 0.001% flurbiprofen (p less then 0.0005). This finding supports the theory that cyclooxygenase products mediate the development of adaptation to exogenous norepinephrine in the rabbit eye.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.