January 1982
Volume 22, Issue 1
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Articles  |   January 1982
Tissue distribution of 3H-hematoporphyrin derivative in athymic "nude" mice heterotransplanted with human retinoblastoma.
Investigative Ophthalmology & Visual Science January 1982, Vol.22, 118-120. doi:
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      C J Gomer, N Rucker, C Mark, W F Benedict, A L Murphree; Tissue distribution of 3H-hematoporphyrin derivative in athymic "nude" mice heterotransplanted with human retinoblastoma.. Invest. Ophthalmol. Vis. Sci. 1982;22(1):118-120.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Quantitative uptake levels of tritium-labeled hematoporphyrin derivative (3H-HpD) have been obtained for normal and malignant tissue of athymic "nude" mice heterotransplanted intraocularly with human retinoblastoma. It was determined that eyes with tumor accumulated higher levels of 3H-HpD than those in control eyes. In addition, an improved therapeutic retention ratio of the drug (eyes with tumor compared with control eyes) was obtained at extended time intervals after administration.

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