June 1982
Volume 22, Issue 6
Free
Articles  |   June 1982
Herpetic keratitis in zinc-deficient rabbits.
Investigative Ophthalmology & Visual Science June 1982, Vol.22, 788-795. doi:
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      L S Feiler, G Smolin, M Okumoto, D Condon; Herpetic keratitis in zinc-deficient rabbits.. Invest. Ophthalmol. Vis. Sci. 1982;22(6):788-795.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

In a study of 57 rabbits, we found that zinc played a vital role in the growth of the rabbit and in its immunocompetence. Both humoral and cellular immunity were depressed in the zinc-deficient rabbit. Not only did zinc-deficient animals fail to gain weight, differing in that respect from rabbits on a regular diet, but they also had a high death rate, in contrast with no deaths among normal rabbits. Herpes simplex virus keratitis, both epithelial and stromal, was more severe in the zinc-deficient rabbit but was not improved by local zinc replacement (zinc sulphate ointment, 0.05%); Zinc sulphate ointment (1%), which is four times stronger than commercially available zinc ophthalmic preparations, was severely toxic for the rabbit cornea.

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