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M Guivernau, A Terragno, M W Dunn, N A Terragno; Estrogens induce lipoxygenase derivative formation in rabbit lens.. Invest. Ophthalmol. Vis. Sci. 1982;23(2):214-217. doi: https://doi.org/.
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The effect of estrogens on arachidonic acid metabolism was studied in lenses from normal and sex hormone-treated female rabbits. Analysis of the metabolites derived from incubation of these lenses with (1-14C) arachidonic acid provides the first evidence that estradiol activates the lipoxygenase pathway, as indicated by 5-S-hydroxy-6,8,11,14-eicosatetraenoic acid--like product formation, an effect that can be prevented by progestin treatment. Prostaglandin synthesis was not demonstrated by the control or estrogen-treated rabbit lenses, suggesting that lipoxygenase is the major arachidonic acid pathway in the lens.
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