August 1982
Volume 23, Issue 2
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Articles  |   August 1982
Estrogens induce lipoxygenase derivative formation in rabbit lens.
Investigative Ophthalmology & Visual Science August 1982, Vol.23, 214-217. doi:https://doi.org/
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      M Guivernau, A Terragno, M W Dunn, N A Terragno; Estrogens induce lipoxygenase derivative formation in rabbit lens.. Invest. Ophthalmol. Vis. Sci. 1982;23(2):214-217. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The effect of estrogens on arachidonic acid metabolism was studied in lenses from normal and sex hormone-treated female rabbits. Analysis of the metabolites derived from incubation of these lenses with (1-14C) arachidonic acid provides the first evidence that estradiol activates the lipoxygenase pathway, as indicated by 5-S-hydroxy-6,8,11,14-eicosatetraenoic acid--like product formation, an effect that can be prevented by progestin treatment. Prostaglandin synthesis was not demonstrated by the control or estrogen-treated rabbit lenses, suggesting that lipoxygenase is the major arachidonic acid pathway in the lens.

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