Purchase this article with an account.
M Guivernau, A Terragno, M W Dunn, N A Terragno; Estrogens induce lipoxygenase derivative formation in rabbit lens.. Invest. Ophthalmol. Vis. Sci. 1982;23(2):214-217.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
The effect of estrogens on arachidonic acid metabolism was studied in lenses from normal and sex hormone-treated female rabbits. Analysis of the metabolites derived from incubation of these lenses with (1-14C) arachidonic acid provides the first evidence that estradiol activates the lipoxygenase pathway, as indicated by 5-S-hydroxy-6,8,11,14-eicosatetraenoic acid--like product formation, an effect that can be prevented by progestin treatment. Prostaglandin synthesis was not demonstrated by the control or estrogen-treated rabbit lenses, suggesting that lipoxygenase is the major arachidonic acid pathway in the lens.
This PDF is available to Subscribers Only