June 1982
Volume 22, Issue 6
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Articles  |   June 1982
13C-nuclear magnetic resonance studies of sugar cataractogenesis in the single intact rabbit lens.
Investigative Ophthalmology & Visual Science June 1982, Vol.22, 808-811. doi:https://doi.org/
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      R G González, J Willis, J Aguayo, P Campbell, L T Chylack, T Schleich; 13C-nuclear magnetic resonance studies of sugar cataractogenesis in the single intact rabbit lens.. Invest. Ophthalmol. Vis. Sci. 1982;22(6):808-811. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

In this report we demonstrate that 13C-nuclear magnetic resonance spectroscopy may be used to monitor the sorbitol and glycolytic pathways in a single, intact, crystalline lens of the rabbit, thereby providing a new, noninvasive method for the study of sugar cataractogenesis. This approach is particularly useful for the measurement of intralenticular metabolic fluxes in single lenses under various conditions, at a time resolution previously unavailable in lens biochemistry.

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