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R G González, J Willis, J Aguayo, P Campbell, L T Chylack, T Schleich; 13C-nuclear magnetic resonance studies of sugar cataractogenesis in the single intact rabbit lens.. Invest. Ophthalmol. Vis. Sci. 1982;22(6):808-811. doi: https://doi.org/.
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In this report we demonstrate that 13C-nuclear magnetic resonance spectroscopy may be used to monitor the sorbitol and glycolytic pathways in a single, intact, crystalline lens of the rabbit, thereby providing a new, noninvasive method for the study of sugar cataractogenesis. This approach is particularly useful for the measurement of intralenticular metabolic fluxes in single lenses under various conditions, at a time resolution previously unavailable in lens biochemistry.
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