August 1982
Volume 23, Issue 2
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Articles  |   August 1982
Effects of intravitreally injected DL-alpha-aminoadipic acid on the c-wave of the D.C.-recorded electroretinogram in albino rabbits.
Investigative Ophthalmology & Visual Science August 1982, Vol.23, 240-245. doi:https://doi.org/
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      E Welinder, O Textorius, S E Nilsson; Effects of intravitreally injected DL-alpha-aminoadipic acid on the c-wave of the D.C.-recorded electroretinogram in albino rabbits.. Invest. Ophthalmol. Vis. Sci. 1982;23(2):240-245. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The D.C. electroretinogram of four adult albino rabbits was studied 13.5 to 15 hr after injection of 0.1 ml of 0.15M DL-alpha-aminoadipic acid (alpha-AAA) into the vitreous body of one eye. The other eye was similarly injected with saline and served as control. In the alpha-AAA--treated eye the b-wave was markedly reduced or absent and the a- and c-waves increased compared with the control eye. Sincs alpha-AAA damages the Müller cells, the results support the view that these cells are related to the generation of the b-wave and to the negative slow PIII-potential, which modifies the positive pigment epithelial component of the c-wave.

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