August 1982
Volume 23, Issue 2
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Articles  |   August 1982
Abnormalities of chromatic and luminance critical flicker frequency in multiple sclerosis.
Investigative Ophthalmology & Visual Science August 1982, Vol.23, 246-252. doi:https://doi.org/
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      R J Mason, R S Snelgar, D H Foster, J R Heron, R E Jones; Abnormalities of chromatic and luminance critical flicker frequency in multiple sclerosis.. Invest. Ophthalmol. Vis. Sci. 1982;23(2):246-252. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Critical flicker frequency (CFF) was measured for stimuli varying in chromaticity only and in luminance only for patients with multiple sclerosis (MS) and for matched normal controls. The two CFF measurements showed different underlying linear interdependencies for the two groups, consistent with a greater loss of temporal luminance function than of temporal chromatic function in MS patients. These results are discussed in relation to the pathophysiology of demyelinated nerve fibers. It is suggested that demyelination affects all types of nerve fiber unselectively; in particular, no support is found for the notion of a special vulnerability of fibers carrying time-varying chromatic information.

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