August 1983
Volume 24, Issue 8
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Articles  |   August 1983
Anterior chamber associated immune deviation induced by TNP-splenocytes (TNP-ACAID). I. Systemic tolerance mediated by suppressor T-cells.
Investigative Ophthalmology & Visual Science August 1983, Vol.24, 1086-1092. doi:
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      J C Waldrep, H J Kaplan; Anterior chamber associated immune deviation induced by TNP-splenocytes (TNP-ACAID). I. Systemic tolerance mediated by suppressor T-cells.. Invest. Ophthalmol. Vis. Sci. 1983;24(8):1086-1092.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The relationship between the anterior chamber (AC) of the eye and the immune system was studied after intracameral inoculation with the hapten TNP. Injection of syngeneic TNP-modified splenocytes (TNP-Sp) into the AC of Balb/c mice results in suppressed systemic cell-mediated immunity to TNP as determined by the ear swelling assay. This aberrant immune responsiveness following AC injection of TNP-Sp has been termed TNP anterior chamber-associated immune deviation or TNP-ACAID. The phenomenon of TNP-ACAID is mediated by antigen-specific efferent suppressor T cells (Ts). The generation of Ts in TNP-ACAID requires a period of interaction between the intact eye and spleen, ie, the splenocameral axis.

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