July 1985
Volume 26, Issue 7
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Articles  |   July 1985
Retinal S-antigen epitopes in vertebrate and invertebrate photoreceptors.
Investigative Ophthalmology & Visual Science July 1985, Vol.26, 1016-1021. doi:
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      M Mirshahi, C Boucheix, G Collenot, B Thillaye, J P Faure; Retinal S-antigen epitopes in vertebrate and invertebrate photoreceptors.. Invest. Ophthalmol. Vis. Sci. 1985;26(7):1016-1021.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Monoclonal antibodies specific for the retinal S-antigen were obtained by hybridization of spleen cells from a BALB/c mouse immunized with bovine S-antigen and NS-1 myeloma cells. Five selected antibodies specifically labeled the photoreceptor cells of the retina by immunofluorescence. Whereas antibody S9E2 only reacted with bovine S-antigen, the other antibodies showed interspecies cross-reactivity. They were used for the characterization of specific epitopes of S-antigen in photoreceptors from a wide range of species representative of various classes of vertebrates and invertebrates. The presence of S-antigen in distant species (vertebrates, Amphioxus, nemerteans, annelids, molluscs) indicates a high phylogenetic stability and suggests an important role for this protein in photoreceptor function.

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