November 1985
Volume 26, Issue 11
Articles  |   November 1985
Distribution patterns of photoreceptors, protein, and cyclic nucleotides in the human retina.
Investigative Ophthalmology & Visual Science November 1985, Vol.26, 1558-1568. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      D B Farber, J G Flannery, R N Lolley, D Bok; Distribution patterns of photoreceptors, protein, and cyclic nucleotides in the human retina.. Invest. Ophthalmol. Vis. Sci. 1985;26(11):1558-1568.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

The concentration of cGMP, cAMP, protein and the number of cone and rod photoreceptors have been measured in parallel arrays of punches, 3 mm in diameter, taken from each quadrant of normal human retinas. A separate punch containing the fovea and parafoveal region was also analyzed. Eyes were obtained from four male donors ranging in age from 35 to 67 yr. The retina thins considerably from the center to the periphery, and consequently the protein content forms a gradient in the same direction. Similar gradients were observed for cAMP and cGMP concentrations. In all eyes studied, the foveal-parafoveal region had higher levels of cAMP than cGMP. The data was analyzed with the aid of a computer in order to obtain three-dimensional maps of the patterns of distribution of the different parameters. A strong correlation between the areas of higher cone density, non-photoreceptor neurons, and cAMP, and an equally strong correlation between rod distribution and that of cGMP was observed. These maps will serve as baseline data in studies of pathological conditions such as retinitis pigmentosa.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.