July 1985
Volume 26, Issue 7
Articles  |   July 1985
Distribution of calpain I, calpain II, and calpastatin in bovine lens.
Investigative Ophthalmology & Visual Science July 1985, Vol.26, 953-956. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      H Yoshida, T Murachi, I Tsukahara; Distribution of calpain I, calpain II, and calpastatin in bovine lens.. Invest. Ophthalmol. Vis. Sci. 1985;26(7):953-956.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Two types of Ca2+-requiring cysteine proteinase (calpain, EC, which required for full activation 100 microM Ca2+ (calpain I) and 1 mM Ca2+ (calpain II) were found to exist in the cytosolic fraction of bovine lens. Since calpain may play an important role on the degradation of lens proteins during the aging process of the lens, we attempted to study the distribution of calpain I, calpain II, and calpastatin (an endogenous specific inhibitor of calpain) in bovine lens. It was found that both the capsule-epithelium and cortex fiber cells contained calpains I and II and calpastatin, although the content of calpain I was much lower than that of calpain II. Calpains I and II and calpastatin activities were not detected in the nuclear region at all.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.