July 1985
Volume 26, Issue 7
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Articles  |   July 1985
Synaptic lamellae of the photoreceptors of pearl and wild-type mice.
Investigative Ophthalmology & Visual Science July 1985, Vol.26, 992-1001. doi:
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      M A Williams, J Gherson, L J Fisher, L H Pinto; Synaptic lamellae of the photoreceptors of pearl and wild-type mice.. Invest. Ophthalmol. Vis. Sci. 1985;26(7):992-1001.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The retina of the pearl mutant mouse, C57BL/6J pe/pe, exhibits reduced light sensitivity in the dark-adapted condition (Balkema and Pinto, J Neurophysiol 48:968, 1982). The authors searched for an anatomic correlate in the retina which could relate to the functional deficit. Electron microscopic mosaics of the outer plexiform layer of light- and dark-adapted pearl and wild-type mice were analyzed. The numerical density and length of the photoreceptor synaptic lamellae showed these parameters to be indistinguishable in wild-type and pearl retinas under conditions of both light- and dark-adaptation. Light-adapted pearl retinas exhibited some rod spherules that contained structurally modified synaptic lamellae with bulbous thickenings and adjacent electron-dense bodies. These lamellar modifications were neither apparent in the light-adapted, wild-type retinas, nor in the dark-adapted retinas of either genotype. Pronase application to ultrathin sections hydrolyzed synaptic lamellae, bulbous thickenings and electron dense bodies.

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