March 1986
Volume 27, Issue 3
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Articles  |   March 1986
Dopamine influences the light peak in the perfused mammalian eye.
Investigative Ophthalmology & Visual Science March 1986, Vol.27, 330-335. doi:
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      S M Dawis, G Niemeyer; Dopamine influences the light peak in the perfused mammalian eye.. Invest. Ophthalmol. Vis. Sci. 1986;27(3):330-335.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Dopamine, cis-flupenthixol, and dibutyryl cAMP affected the standing potential and light-evoked responses of the perfused cat eye in vitro. At micromolar concentrations, dopamine, a retinal neurotransmitter, increased the standing potential of the eye. At slightly higher concentrations, dopamine abolished the "light peak," a slow voltage response to light generated by the retinal pigment epithelium. The light peak was depressed by cis-flupenthixol, a dopamine antagonist, at micromolar concentrations. Dibutyryl cAMP produced effects similar to those produced by dopamine. A possible interpretation is that the generation of the light peak involves a catecholamine-stimulated adenylate cyclase in retinal pigment epithelium that is influenced by dopamine released from retinal neurons.

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