March 1986
Volume 27, Issue 3
Articles  |   March 1986
Dopamine influences the light peak in the perfused mammalian eye.
Investigative Ophthalmology & Visual Science March 1986, Vol.27, 330-335. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      S M Dawis, G Niemeyer; Dopamine influences the light peak in the perfused mammalian eye.. Invest. Ophthalmol. Vis. Sci. 1986;27(3):330-335.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Dopamine, cis-flupenthixol, and dibutyryl cAMP affected the standing potential and light-evoked responses of the perfused cat eye in vitro. At micromolar concentrations, dopamine, a retinal neurotransmitter, increased the standing potential of the eye. At slightly higher concentrations, dopamine abolished the "light peak," a slow voltage response to light generated by the retinal pigment epithelium. The light peak was depressed by cis-flupenthixol, a dopamine antagonist, at micromolar concentrations. Dibutyryl cAMP produced effects similar to those produced by dopamine. A possible interpretation is that the generation of the light peak involves a catecholamine-stimulated adenylate cyclase in retinal pigment epithelium that is influenced by dopamine released from retinal neurons.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.