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M R Hernandez, B I Weinstein, M W Dunn, G G Gordon, A L Southren; The effect of dexamethasone on the synthesis of collagen in normal human trabecular meshwork explants.. Invest. Ophthalmol. Vis. Sci. 1985;26(12):1784-1788.
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This study demonstrates that the trabecular meshwork cells of the human eye incorporate 3H-Proline into collagen during in vitro incubation. Addition of dexamethasone to the incubation mixture produced a marked decrease in this incorporation. Dexamethasone was active at 10(-8) M and higher concentrations. The specificity of the hormone effect was demonstrated by its inability to alter 3H-leucine incorporation in these cells. These results indicate that dexamethasone decreases the synthesis of collagen, a major component of the extracellular matrix, in the trabecular meshwork.
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