September 1985
Volume 26, Issue 9
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Articles  |   September 1985
In vitro enhancement of anterior chamber GVH reactions.
Investigative Ophthalmology & Visual Science September 1985, Vol.26, 1252-1256. doi:
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      A A Khodadoust, M Farazdaghi, A M Silverstein, R A Prendergast; In vitro enhancement of anterior chamber GVH reactions.. Invest. Ophthalmol. Vis. Sci. 1985;26(9):1252-1256.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The injection of sensitized allogeneic lymphocytes into the anterior chamber of the rabbit eye results in a local graft-verus-host reaction, with focal destruction of the corneal endothelium. This experimental model permits in vitro manipulation of effector cells, and the study of the mechanisms involved in corneal graft rejection. The authors now show that the in vitro activation of sensitized lymphocytes is a one-way mixed lymphocyte reaction yields "supersensitized" effector cells which are quantitatively enriched and qualitatively altered to yield more severe and more rapid endothelial target cell destruction.

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