November 1985
Volume 26, Issue 11
Articles  |   November 1985
Hydration stability of intracorneal hydrogel implants.
Investigative Ophthalmology & Visual Science November 1985, Vol.26, 1634-1636. doi:
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      W H Beekhuis, B E McCarey; Hydration stability of intracorneal hydrogel implants.. Invest. Ophthalmol. Vis. Sci. 1985;26(11):1634-1636.

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      © ARVO (1962-2015); The Authors (2016-present)

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A hydrogel intracorneal lens for refractive keratoplasty must have predictable and stable optics when implanted in the corneal stroma. A series of experiments was performed to evaluate the hydrogel hydration stability when in the corneal stromal environment. Hydrogel ICLs of 54%, 63%, 66% and 71% water content showed no loss of hydration (by weight) after one week in the rabbit corneal stroma. In vitro experiments with hydrogel discs of 56%, 65%, 69.5% and 75% water content were subjected to swelling pressures ranging from 55 to 150 mmHg in a suction chamber. Only the hydrogel of 75% water content showed a significant loss of hydration at the physiologic swelling pressure of 55 mmHg. This study shows that hydrogel materials with up to 69.5% water content can be expected to be dimensionally stable when used in keratorefractive surgery.


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