April 1986
Volume 27, Issue 4
Articles  |   April 1986
Human basement membrane components of keratoconus and normal corneas.
Investigative Ophthalmology & Visual Science April 1986, Vol.27, 604-607. doi:
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      J A Millin, B M Golub, C S Foster; Human basement membrane components of keratoconus and normal corneas.. Invest. Ophthalmol. Vis. Sci. 1986;27(4):604-607.

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      © ARVO (1962-2015); The Authors (2016-present)

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Using immunofluorescence techniques, we analyzed the distribution of glycoproteins in normal and keratoconus corneas of humans. Laminin, bullous pemphigoid antigen, fibronectin, and fibrin/fibrinogen were all found in the epithelial basement membrane of normal corneas. Keratoconus corneas produced similar results, except that staining for fibrin/fibrinogen was weak. Fibrin/fibrinogen was absent from normal corneal basement membrane in animal models studied previously. Keratoconus may be the result of the lysis of fibrin or may involve impeded elaboration of fibrin.


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