March 1986
Volume 27, Issue 3
Free
Articles  |   March 1986
Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium.
Investigative Ophthalmology & Visual Science March 1986, Vol.27, 364-371. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P L Penfold, M C Killingsworth, S H Sarks; Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium.. Invest. Ophthalmol. Vis. Sci. 1986;27(3):364-371.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Senile macular degeneration (SMD) is a leading cause of registered blindness in the United States and other Western countries. Loss of central vision develops as a result of atrophy of the retinal pigment epithelium or subretinal neovascularisation. The histopathology of the atrophic form of SMD has not been extensively studied. This paper illustrates at the light and electron microscope level the involvement the atrophic form of SMD. Additional features including pigment clumping and detachment of the retinal pigment epithelium at the advancing edge of the lesion are illustrated. Giant cells and MPS cells are typical features of granulomatous inflammation, and results suggest that they may play a role in the pathogenesis of SMD.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×