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C A Tabatabay, D J D'Amico, L A Hanninen, V N Casey, K R Kenyon; Residual bodies in the retinal pigment epithelium induced by intravitreal netilmicin.. Invest. Ophthalmol. Vis. Sci. 1987;28(11):1783-1787.
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© ARVO (1962-2015); The Authors (2016-present)
Intravitreal injection of aminoglycoside antibiotics is known to induce morphological changes in the retinal pigment epithelium (RPE) resembling a lipidosis. The RPE of netilmicin-treated rabbits displays a dose-related increase in autofluorescence compared to untreated controls. Netilmicin produces an accumulation of membrane-limited osmiophilic lamellated inclusions in the pigment epithelial cell. These inclusions measure from 1 to 3 microns in diameter, and have acid hydrolase activity demonstrated by cytidine monophosphate cytochemistry. These findings suggest that netilmicin-induced inclusions are residual bodies and that the accumulation of these residual bodies is responsible for the observed cellular lipidosis.
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