January 1986
Volume 27, Issue 1
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Articles  |   January 1986
Movement of fluorescein monoglucuronide in the rabbit cornea. Diffusion in the stroma and endothelial permeability.
Investigative Ophthalmology & Visual Science January 1986, Vol.27, 24-28. doi:
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      K Shiraya, S Nagataki; Movement of fluorescein monoglucuronide in the rabbit cornea. Diffusion in the stroma and endothelial permeability.. Invest. Ophthalmol. Vis. Sci. 1986;27(1):24-28.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The movement of fluorescein monoglucuronide, a fluorescent metabolite of fluorescein, was studied in the rabbit cornea in vitro and in vivo. A stromal strip was exposed to fluorescein monoglucuronide, and the diffusion rate and the distribution in the stroma were measured every hr for 24 hr. The diffusion coefficient was 0.94 +/- 0.11 (+/- S.D.) X 10(-6) cm2/sec, and the saline/stroma distribution ratio was in a range of 0.67 to 0.69. The concentration of fluorescein monoglucuronide in the anterior chamber and the cornea was measured every hr for 8 hr following intravenous administration. The endothelial permeability was 4.7 +/- 1.0 X 10(-4) cm/min, and the aqueous/cornea distribution ratio was 0.56 +/- 0.05. It appears that the corneal endothelial permeability in the living eye determined hitherto from systemic administration of fluorescein is most likely the permeability to fluorescein monoglucuronide.

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