June 1986
Volume 27, Issue 6
Free
Articles  |   June 1986
Comparative replication of HSV-1 in BALB/c and C57BL/6 mouse embryo fibroblasts in vitro.
Investigative Ophthalmology & Visual Science June 1986, Vol.27, 909-914. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      S Z Abghari, R D Stulting, S M Nigida, D N Downer, A J Nahmias; Comparative replication of HSV-1 in BALB/c and C57BL/6 mouse embryo fibroblasts in vitro.. Invest. Ophthalmol. Vis. Sci. 1986;27(6):909-914.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Herpes simplex virus type 1 (HSV)-host cell interactions were studied in fibroblasts from inbred mice by measuring virus replication, virus adsorption, infectious center formation, and single-cell virus production. BALB/c mouse embryo fibroblasts (MEF) produced more intracellular and extracellular virus than C57BL/6 MEF, with differences in virus production first appearing at 16 hr after inoculation. Virus yield in C57BL/6 cells peaked earlier (16 hr) and at a lower level than in BALB/c cells (20 hr). These results were explained by a difference in single-cell virus replication, rather than less efficient adsorption or the presence of cells that could not be infected. Host-related variation in the ability of infected cells to support HSV replication may account, in part, for differences in the severity of HSV ocular disease.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×