January 1988
Volume 29, Issue 1
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Articles  |   January 1988
Presence of Langerhans cells in the cornea of Klebsiella keratoconjunctivitis mice.
Author Affiliations
  • E García-Olivares
    Department of Physiology and Biochemistry, Faculty of Medicine, Granada, Spain.
  • B Carreras
    Department of Physiology and Biochemistry, Faculty of Medicine, Granada, Spain.
  • J M Gallardo
    Department of Physiology and Biochemistry, Faculty of Medicine, Granada, Spain.
Investigative Ophthalmology & Visual Science January 1988, Vol.29, 108-111. doi:
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      E García-Olivares, B Carreras, J M Gallardo; Presence of Langerhans cells in the cornea of Klebsiella keratoconjunctivitis mice.. Invest. Ophthalmol. Vis. Sci. 1988;29(1):108-111.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Frozen sections of normal Balb/c corneas and corneas from Balb/c mice with Klebsiella keratoconjunctivitis were examined for the expression of class I, class II H-2 antigens and MAC-1 antigens using monoclonal antibodies in an immunoperoxidase technique. Class I antigens were readily detected, in both normal and diseased corneas, mainly in the epithelium. Class II (Ia) and MAC-1 antigens were not detected in the normal corneas. However, these two antigens were found mainly in the epithelium and to a lesser extent in the stroma of corneas from keratoconjunctivitis mice. Both normal and diseased corneas were furthermore shown to be peroxidase-. Since Langerhans cells (LC) are Ia+, MAC-1+, and peroxidase- cells, we conclude that although the normal mouse cornea is devoid of these cells, under bacterial infection LC infiltrate the corneal epithelium.

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