August 1985
Volume 26, Issue 8
Free
Articles  |   August 1985
Prostaglandins E3 and D3 lower intraocular pressure.
Investigative Ophthalmology & Visual Science August 1985, Vol.26, 1178-1182. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P S Kulkarni, B D Srinivasan; Prostaglandins E3 and D3 lower intraocular pressure.. Invest. Ophthalmol. Vis. Sci. 1985;26(8):1178-1182.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

The effects of the prostaglandin (PG)-3 series products PGE3 and PGD3 on the intraocular pressure of rabbits were studied. PGE3 at 0.001 and 0.01 mg/eye and PGD3 at 0.01 and 0.05 mg/eye doses were applied topically (in 50-microliters volume) to the normal rabbit eye. Both PGE3 and PGD3 significantly lowered intraocular pressure at all doses tested and the IOP lowering response lasted at least 240 min. Topical PGE3 at 0.01 mg/eye caused mild conjunctival hyperemia which lasted up to 180 min. PGD3, on the other hand, did not induce conjunctival hyperemia. In addition, following application of these PGs, there was no miosis or other sign of intraocular inflammation detectable by slit-lamp examination.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×