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G Ferrari-Dileo, E B Davis, D R Anderson; Angiotensin binding sites in bovine and human retinal blood vessels.. Invest. Ophthalmol. Vis. Sci. 1987;28(11):1747-1751.
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Blood vessels isolated from bovine and human retinas have sites that specifically bind 3H-angiotensin II (3H-Ag II) with an apparent dissociation constant (Kd) of 14 nM and a capacity of binding (Bmax) of 0.82 pmol/g. The binding sites for 3H-Ag II appear to be influenced by guanine nucleotides (GTP) and cations (Mg2+ and Na+) in a way that resembles angiotensin II receptors in other tissues. The physiologic effect of blood-borne or locally-formed angiotensin II on retinal blood flow remains to be defined.
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