January 1988
Volume 29, Issue 1
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Articles  |   January 1988
The effects of D-penicillamine and daunorubicin on conjunctival fibroblast proliferation and collagen synthesis.
Author Affiliations
  • L J McGuigan
    Glaucoma Service, Wilmer Institute, Johns Hopkins Hospital, Baltimore, MD 21205.
  • H A Quigley
    Glaucoma Service, Wilmer Institute, Johns Hopkins Hospital, Baltimore, MD 21205.
  • G Lutty
    Glaucoma Service, Wilmer Institute, Johns Hopkins Hospital, Baltimore, MD 21205.
  • C Enger
    Glaucoma Service, Wilmer Institute, Johns Hopkins Hospital, Baltimore, MD 21205.
  • E Young
    Glaucoma Service, Wilmer Institute, Johns Hopkins Hospital, Baltimore, MD 21205.
Investigative Ophthalmology & Visual Science January 1988, Vol.29, 112-118. doi:
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    • Get Citation

      L J McGuigan, H A Quigley, G Lutty, C Enger, E Young; The effects of D-penicillamine and daunorubicin on conjunctival fibroblast proliferation and collagen synthesis.. Invest. Ophthalmol. Vis. Sci. 1988;29(1):112-118.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Two drugs, D-penicillamine and daunorubicin, were tested for their effect on proliferation and collagen synthesis of cultured conjunctival fibroblasts. This cell type is likely responsible for scar formation and ultimate filter surgery failure in glaucoma patients. Both drugs were antiproliferative; however, D-penicillamine required 2000 times the concentration of daunorubicin to achieve a similar degree of inhibition. D-penicillamine had a more consistent effect on intracellular collagen synthesis than daunorubicin at the doses tested. In contrast, at concentrations of daunorubicin where all proliferation ceased, intracellular production and extracellular transport of collagen were maintained.

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