March 1986
Volume 27, Issue 3
Articles  |   March 1986
Covalent changes in MIP26K during aging of the human lens membrane.
Investigative Ophthalmology & Visual Science March 1986, Vol.27, 443-446. doi:
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      L Takemoto, M Takehana, J Horwitz; Covalent changes in MIP26K during aging of the human lens membrane.. Invest. Ophthalmol. Vis. Sci. 1986;27(3):443-446.

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      © ARVO (1962-2015); The Authors (2016-present)

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Rabbit antisera have been made to the C-terminal octapeptide of bovine MIP26K (residues 256-263) and to an octapeptide near the C-terminus (residues 252-259). Use of these antisera in Western blot analysis of membrane from young vs old human lenses, and from cortex vs nucleus of old human lenses, suggest age-related covalent changes in the C-terminus of MIP26K. These age-related changes in anti-256-263 and anti-252-259 sera can be mimicked by treatment of lens membrane with carboxypeptidase Y, suggesting the loss of 1-8 amino acid residues from the C-terminus of the 26,000 dalton form of MIP26K during aging of the normal human lens.


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