January 1988
Volume 29, Issue 1
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Articles  |   January 1988
Regional distribution of glutathione peroxidase and Glutathione-S-transferase in adult and premature human retinas.
Author Affiliations
  • M I Naash
    Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.
  • J C Nielsen
    Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.
  • R E Anderson
    Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.
Investigative Ophthalmology & Visual Science January 1988, Vol.29, 149-152. doi:
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      M I Naash, J C Nielsen, R E Anderson; Regional distribution of glutathione peroxidase and Glutathione-S-transferase in adult and premature human retinas.. Invest. Ophthalmol. Vis. Sci. 1988;29(1):149-152.

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Abstract

The activities of glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GSH-S-tase) were investigated in adult and premature human retinas. The measurements were done in the vascular and avascular regions of premature retinas at gestational age of 22-33 weeks and in the central, mid-peripheral, and far peripheral regions of mature retinas from the age of 1 month to 73 years. Among the premature infants, those who survived for greater than 24 hours were supplemented with alpha-tocopherol (vitamin E) on a periodic basis. The vascular and avascular regions of premature retinas had higher activities of GSH-Px when compared to the central and far peripheral regions of mature retinas. Infants surviving more than 24 hr had higher activities of GSH-S-tase in the avascular region than infants who survived less than 24 hr. Survival did not affect either enzyme activity in the vascular regions. Mature retinas showed a decrease in GSH-Px specific activity with age, but no age-related changes in GSH-S-tase were observed. These data demonstrate that premature infants are born with relatively high levels of GSH-Px and GSH-S-tase.

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