August 1963
Volume 2, Issue 4
Articles  |   August 1963
Passage Out of the Eye of Substances of Low and High Molecular Weights
Author Affiliations
    Departments of Pharmacology and Ophthalmology, University of Uppsala, Sweden
Investigative Ophthalmology & Visual Science August 1963, Vol.2, 305-315. doi:
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      LENNART BERGGREN; Passage Out of the Eye of Substances of Low and High Molecular Weights. Invest. Ophthalmol. Vis. Sci. 1963;2(4):305-315.

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      © ARVO (1962-2015); The Authors (2016-present)

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Perfusion of the anterior chamber of albino rabbit eyes with uncharged molecules of different molecular weights has shown that passage out of the eye does not occur as unimpeded fiow, but is influenced by the presence of spaces with different accessibilities leading to the separation of molecules of different sizes. Small molecules are retarded more than macromolecules, and appear later in the perfusate. It is suggested that this is partly caused by the fact that small molecules contrary to macromolecules are able to penetrate into the hyaluronic acid in the chamber angle region, and that a situation similar to gel filtration exists in the rabbit eye. The distribution of the molecules under different conditions made it possible to estimate the volumes of the spaces involved and their conceivable sites of location.


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