April 1988
Volume 29, Issue 4
Free
Articles  |   April 1988
Carbon disulfide effects on the visual system. I. Visual thresholds and ophthalmoscopy.
Author Affiliations
  • W H Merigan
    Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, NY 14642.
  • R W Wood
    Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, NY 14642.
  • D Zehl
    Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, NY 14642.
  • T A Eskin
    Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, NY 14642.
Investigative Ophthalmology & Visual Science April 1988, Vol.29, 512-518. doi:
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    • Get Citation

      W H Merigan, R W Wood, D Zehl, T A Eskin; Carbon disulfide effects on the visual system. I. Visual thresholds and ophthalmoscopy.. Invest. Ophthalmol. Vis. Sci. 1988;29(4):512-518.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The visual effects of carbon disulfide exposure were studied in macaque monkeys with measurements of visual thresholds, fluorescein angiography and fundus photography. Five monkeys were exposed by inhalation for 6 hr a day, 5 days a week to 256 ppm carbon disulfide (CS2). The motor dysfunction observed in these monkeys appeared to be entirely reversible. All five suffered severe reductions in visual acuity and contrast sensitivity although flicker resolution was not affected. Visual loss was found to be irreversible, with degeneration of substantial numbers of retinal ganglion cells (companion paper) in those monkeys permitted to survive after the termination of exposure. None of the monkeys developed retinal microaneurysms or hemorrhages, major accepted signs of visual toxicity in CS2 exposed humans; thus, permanent visual loss may result from carbon disulfide exposure even in the absence of retinal vascular effects.

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