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BERNARD BECKER; Ouabain and Aqueous Humor Dynamics in the Rabbit Eye. Invest. Ophthalmol. Vis. Sci. 1963;2(4):325-331.
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Intravenous injections of ouabain in doses as high as 100 to 250 mcg. per kilogram failed to alter intraocular pressure in rabbits. The injection into the vitreous humor of one eye of as little as 0.5 mcg. of ouabain resulted in a pronounced unilateral decrease in intraoculai pressure. At 4 to 5 days after injection the pressure in the injected eye was significantly lower (mean 7.1 mm. Hg) than that of the opposite eye. Comparisons of tonographic tracings and. of anterior and posterior aqueous humor concentrations of bicarbonate, ascorbate, and protein were compatible with reductions in the rate of aqueous flow in the ouabain-treated eyes to 27 to 32 per cent of the normal eyes.
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