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MARGUERITE A. CONSTANT, JOHN FALCH; Phosphate and Protein Concentrations of Intraocular Fluids I. Effect of Carbonic Anhydrase Inhibition in Young and Old Rabbits. Invest. Ophthalmol. Vis. Sci. 1963;2(4):332-343.
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© ARVO (1962-2015); The Authors (2016-present)
The effects of a carbonic anhydrase inhibitor, dichlorphenamide, on the phosphate and protein concentrations of intraocular fluids have been studied.
The administration of dichlorphenamide caused a marked increase in phosphate concentration of posterior and anterior aqueous humors. The changes in steady-state concentrations were compatible with a decrease in the flow coefficient of approximately 54 per cent.
Simultaneous treatment toith probenecid has been found to prolong the inhibitory effect on aqueous secretion of a single dose of dichlorphenamide as measured by tonography and by phosphate concentrations in intraocular fluids.
The protein concentrations in intraocular fluids of the experimental eyes were not significantly different from those of the control eyes.
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