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L Schweigerer, G Neufeld, D Gospodarowicz; Basic fibroblast growth factor is present in cultured human retinoblastoma cells.. Invest. Ophthalmol. Vis. Sci. 1987;28(11):1838-1843.
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Cultured human retinoblastoma cells express the basic fibroblast growth factor (bFGF) gene and they produce material similar, if not identical, to bFGF. The retinoblastoma-derived bFGF can stimulate the proliferation of capillary endothelial cells and this process is inhibited by anti-bFGF antibodies. It is conceivable that the retinoblastoma-derived bFGF contributes to the neovascularization of retinoblastomas.
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