June 1988
Volume 29, Issue 6
Free
Articles  |   June 1988
Increased ocular blood flow and 125I-albumin permeation in galactose-fed rats: inhibition by sorbinil.
Author Affiliations
  • R G Tilton
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
  • K Chang
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
  • C Weigel
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
  • D Eades
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
  • W R Sherman
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
  • C Kilo
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
  • J R Williamson
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
Investigative Ophthalmology & Visual Science June 1988, Vol.29, 861-868. doi:
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      R G Tilton, K Chang, C Weigel, D Eades, W R Sherman, C Kilo, J R Williamson; Increased ocular blood flow and 125I-albumin permeation in galactose-fed rats: inhibition by sorbinil.. Invest. Ophthalmol. Vis. Sci. 1988;29(6):861-868.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

125I-Albumin permeation and blood flow (assessed with 15 micron, 85Sr-labelled microspheres) were determined in the retina, choroid, anterior uvea, and brain of male Sprague-Dawley rats fed diets containing 50% dextrin (control) or 50% galactose. Blood flow was increased in the retina, choroid, and anterior uvea but not in the brain of rats fed galactose for 3 weeks and 3 months versus controls, and was normalized by sorbinil (an inhibitor of aldose reductase) in the 3-week group. After 8 months of galactose feeding, blood flow was reduced to normal levels in the retina and was slightly below normal in the choroid; blood flow remained elevated in the anterior uvea but was significantly lower than that observed at 3 weeks and at 3 months. In rats fed galactose for 8 months, sorbinil completely normalized blood flow in the choroid, and decreased, but did not normalize, blood flow in the anterior uvea. 125I-Albumin permeation was increased in the retina, choroid, and anterior uvea of rats fed 50% galactose for 3 weeks, 3 months, and 8 months versus controls, but was unchanged in the brain. Sorbinil normalized 125I-albumin permeation in all three ocular tissues in 8-month galactose-fed rats. Polyol levels were increased significantly in all three ocular tissues of 3-week galactose-fed rats; sorbinil markedly decreased, but did not normalize, polyol levels in all three tissues.(ABSTRACT TRUNCATED AT 250 WORDS)

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