August 1963
Volume 2, Issue 4
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Articles  |   August 1963
The Fate of Cells in Heterologous Corneal Transplants
Author Affiliations
  • FRANK M. POLACK
    Department of Ophthalmology, College of Physicians and Surgeons, New York, N. Y.; Special Fellow, National Institutes of Health (BT-819)
  • GEORGE K. SMELSER
    Department of Ophthalmology, College of Physicians and Surgeons, New York, N. Y.
  • JEANETTE ROSE
    Department of Ophthalmology, College of Physicians and Surgeons, New York, N. Y.
Investigative Ophthalmology & Visual Science August 1963, Vol.2, 355-360. doi:https://doi.org/
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      FRANK M. POLACK, GEORGE K. SMELSER, JEANETTE ROSE; The Fate of Cells in Heterologous Corneal Transplants. Invest. Ophthalmol. Vis. Sci. 1963;2(4):355-360. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The fate of intralamellar corneal heterografts was investigated by radioautography. The corneal connective tissue cells of rabbit eyes were labeled with tritiated thytnidine and. grafted intralamellarly into cat corneas. In 8 out of 9 clear transplants, radioautographs demonstrated that the donor cells had persisted in grafts varying in age from 2 to 10 months. Donor cells were not found in 4 opaque grafts. In additional experiments the possibility of host cells being labeled by radioactive material from dead donor cells was investigated. There was no radioauto graphic evidence of reutilization of labeled nuclear debris.

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